產(chǎn)品概述

Semaphorin 4D (Sema4D, CD100) is a member of a family of transmembrane and secreted proteins that regulates key cellular functions and is involved in cell-cell communication (Kruger et al., 2005; Nkyimbeng-Takwi and Chapoval, 2011; Yazdani and Terman, 2006). Most of the effects of Semaphorin 4D are mediated by plexins (Janssen et al., 2012; Suzuki et al., 2008). Semaphorin 4D participates in numerous physiological processes such as axon guidance, immune regulation, angiogenesis, tumor progression, and bone metabolism (Conrotto et al., 2005; Negishi-Koga et al., 2011a; Negishi-Koga and Takayanagi, 2012; Takamatsu and Kumanogoh, 2012). Cleavage of Semaphorin 4D near the cell membrane through matrix metalloproteinases leads to the biologically active soluble Semaphorin 4D with a molecular weight of 120 kD consisting of 713 amino acids (Maleki et al., 2016; Nkyimbeng-Takwi and Chapoval, 2011; Suzuki et al., 2008). Semaphorin 4D has emerged as a novel therapeutic target in cancer and in bone diseases (Fisher et al., 2016; Yufeng Zhang et al., 2015). Semaphorin 4D is widely studied for its role in neural connectivity, vascularization, cell migration, immune responses, tumor progression, and bone remodeling.